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Translational regulation in mycobacteria and its implications for ...
WebIt is known that under conditions of nutrient starvation, transcription of leaderless genes is upregulated and associated with genes expressed in nondividing cells (Cortes et al., 2013), but understanding of the impact of this regulation on translation is lacking. WebNov 4, 2015 · Leaderless transcripts are likely recognized by 70S ribosomes, rather than the 30S subunit [ 30 – 32 ]. 70S binding is stimulated by initiation-factor 2 [ 33 ], whereas initiation-factor 3 inhibits leaderless translation likely by destabilizing codon-anticodon interactions [ 33, 34 ], an effect enhanced by the S1 protein [ 32, 35 – 37 ]. incolink phone number
Leaderless Transcripts and Small Proteins Are Common Features …
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