Ctcf is a barrier for 2c-like reprogramming
WebCTCF is a barrier for 2C-like reprogramming Nature Communications August 11, 2024 See publication Following Trypanosoma cruzi RPA … WebMar 7, 2024 · Perturbations that slow replication fork speed promote 2-cell-like cell emergence and improve somatic cell nuclear transfer reprogramming and formation of …
Ctcf is a barrier for 2c-like reprogramming
Did you know?
WebVariants of the extracellular chaperone Clusterin are associated with Alzheimer’s disease (AD) and Clusterin levels are elevated in AD patient brains. WebSep 7, 2024 · CTCF is a Barrier for Totipotent-like Reprogramming. Organism. Mus musculus. Experiment type. Genome binding/occupancy profiling by high throughput sequencing. Other. Summary. This SuperSeries is composed of the SubSeries listed below.
WebDec 22, 2024 · However, the molecular determinants of 2C-like conversion have not been completely elucidated. Here, we show that CTCF is a barrier for 2C-like reprogramming. Indeed, forced conversion to a 2C-like state by DUX expression was associated with DNA damage at a subset of CTCF binding sites. WebAug 11, 2024 · Based on the observed CTCF-associated DNA damage in DOX-induced ESC Dux, we speculated that CTCF might represent a barrier for the reprogramming to a 2C-like state. This idea was... We would like to show you a description here but the site won’t allow us.
WebMany attempts have been made to induce high-quality embryonic stem cells such as pluripotent stem cells and totipotent stem cells, but challenges remain to be overcome such as appropriate methods and sources. Demethylation of the genome after WebInterestingly, a rare population of cells with totipotent-like potential, known as 2 cell (2C)-like cells, has been identified within ESC cultures. They arise from (PDF) CTCF is a barrier for 2C-like reprogramming Raphael Pavani - Academia.edu
WebOct 18, 2024 · CTCF controls the metabolic switch occurring at the morula-to-blastocyst transition Summary The eukaryotic genome is organized in 3D at different scales. This structure is driven and maintained by different chromatin states and by architectural factors, such as the zinc finger protein CTCF.
WebCTCF is a barrier for 2C-like reprogramming – DOAJ. Embryos at the 2-cell (2C) stage are totipotent, and overexpression of Dux transcription factor convert embryonic stem … list of all american pie moviesWebMar 3, 2024 · In both Calu-3 (Fig. 1A) and 16HBE14o- (Suppl. Fig. S-IIIA) cells, the most significant motifs were those for CCCTC-Binding Factor (CTCF) (Bell, West and Felsenfeld, 1999) and BORIS/CCCTC-Binding Factor Like (CTCFL)(Loukinov, Pugacheva, Vatolin et al., 2002). Also enriched at sites of BRD8 occupancy in both Calu-3 and 16HBE14o- … list of all american dad christmas episodesWebAug 11, 2024 · [Nature Communications] Researchers showed that the CCCTC-binding factor (CTCF) was a barrier for 2C-like reprogramming. Depletion of CTCF in ESCs … list of all american girl dolls ever madeWebCTCF is a Barrier for Totipotent-like Reprogramming Relations BioProject PRJNA693454 SRA SRP302520 Supplementary file Size Download File type/resource … images of gray tiled showersWebCTCF is a barrier for 2C-like reprogramming. T Olbrich, M Vega-Sendino, D Tillo, W Wu, N Zolnerowich, R Pavani, ... Nature Communications 12 (1), 4856, 2024. 28: 2024: Methylated cytosines mutate to transcription factor … list of all american car brandsWebNov 17, 2024 · Our analysis showed similar transcriptomes of 2CLCs in the presence and absence of CTCF, both with up-regulation of 2C-specific genes and down-regulated pluripotent genes as compared to ESCs (Supplementary Figure S5E), demonstrating that 2CLCs converted in the absence of CTCF is indeed in a 2C-like state. Taken together, … list of all american holidaysWebJan 20, 2024 · Induction of 2C or 4C-like cells has also been done with chemical inhibitors, which could promote totipotent cells in ESC culture. This method could also be the promotion of 2C cells in ESC... images of great horned owls