Web2 nov 2024 · asah1的突变与播散性脂质肉芽肿病 (farber disease)和伴有肌阵挛性癫痫的脊髓性肌萎缩症有关1。 也有人提出asah1的过表达在胶质母细胞瘤的辐射抗性和复发性胶质 … Web21 mar 2024 · Entrez Gene Summary for FTH1 Gene. This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues.

脊髓性肌萎缩症遗传学诊断专家共识 - 中华医学杂志

Web肿瘤发生是一个多因素作用、多阶段发展的过程，其中原癌基因的激活与抑瘤基因的失活是最为重要的事件。. 支架蛋白SASH1基因在多种肿瘤中表达下调或缺失，被认为是一个抑 … Web结论1.ASAH1基因与精神分裂症连锁,ASAH1基因可能是中国汉族人群精神分裂症的位置性易感基因。 2.ASAH1基因上可能存在着精神分裂症的症状数量性状位点。 3.抗精神病药物可能降低有精神疾病家族史的精神分裂症患者ASAH1基因表达水平。 4.ASAH1基因的表达量与精神分裂症患者的症状类型及症状严重程度可能无关。 神经胶质细胞生长因子1 (NRG-1) … buy talk home calling card

ASAH1 N-acylsphingosine amidohydrolase 1 [ (human)]

ASAH1 expression is upregulated following radiation, suggesting it plays a role in conferring radioresistance to glioblastoma and in the development of recurrent glioblastoma. Inhibiting the activity of ASAH1 with carmofur, a drug that has been approved for clinical treatment of colorectal cancers in several countries, leads to substantial cell deaths and as a result has been proposed as a drug target in the treatment of glioblastoma. It has also been suggested to be a novel drug tar… Web鞘脂代谢关键酶-ASAH1-酸性神经酰胺酶(N—acylsphingosineamidohydrolase1,ASAH1)是鞘脂代谢的关键酶,其水解神经酰胺,生成鞘氨醇,继而代谢为鞘氨醇-1-磷酸(sphin-gosine-1-phosphate,S1P)。神经酰胺是鞘磷脂代谢中心分子,传递生长阻滞与凋亡。S1P促进细胞增殖及抑制细胞凋亡。 Web2 set 2024 · N-acylsphingosine amidohydrolase (ASAH1; EC 3.5.1.23), or acid ceramidase (AC), is responsible for the degradation of ceramide into sphingosine and free fatty acids … buy talk home card online to use instantly